Hypercholesterolemia is a condition wherein the cholesterol level in the body exceeds the normal state. Hypercholesterolemia can increase the risk of atherosclerosis, coronary heart disease, pancreatitis. In Indonesia, the development of traditional medicinal plants is carried out by examining herbs known for hereditary efficacy including cinnamon (Cinnamomum burmanii). Of the various nutritious components contained in cinnamon, cinnamaldehyde is a substance that able to reduce cholesterol and triglyceride levels by activating enzymes in liver to be secreted in certain amounts involved in the synthesis of bile acids. Objective.

This research was conducted to determine the efficacy of cinnamon on reducing total cholesterol levels from mice (Mus musculus) which were given high fat feed. Method. The research is experimental with pre-post control study design. Samples and groupings are done by simple random sampling method. The sample consisted of 5 groups: i. Negative control of aquades; II. positive control of high-fat feed (PTL); III. PTL + Cinnamon Extract (EKM) dose 2mg/20 gBB; IV. PTL + EKM dose 4mg/20gBB and PTL + EKM dose 8mg/20gBB. The study was conducted for 28 days.

Provision of EKM begins on days 15-28. Measurement of total cholesterol and body weight of mice on day 0, day 14 and day 28. Results. The results of this study showed that there was a significant decrease in total cholesterol of mice (p = 0.001) given cinnamon extract and there was no significant relationship to body weight of mice (p = 0.419).